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This multi-agonist strategy has potential to become the most effective pharmacological approach to reversing obesity and related metabolic disorders [32, 25]
The primary risks include gastrointestinal side effects (nausea, vomiting, diarrhoea), undesirable weight loss in patients at risk of malnutrition, delayed gastric emptying that may impair levodopa absorption, and rare but serious complications such as pancreatitis and dehydration leading to acute kidney injury
Small-molecule oral drugs change that math: they are cheaper to manufacture, easier to store, and remove the injection barrier that keeps some people off treatment entirely
J Proteomics
Data availability The human genotyping data generated in this study have been deposited in the dbGAP database under accession code phs002025.v1.p1[ and phs003718.v1 [ phs003718.v1.p1]
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